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Search Results for " cancer chemotherapy "

20

Compounds

Cat No. Product Name Synonyms Targets
T2747 Endothall Others
Endothall is an effective protein phosphatase 2A (PP2A) inhibitor, exerting inhibitory effects on both PP2A and PP1, with IC50 values of 90 nM and 5 µM, respectively. It exhibits anticancer activity, making it suitable f...
T9271 RAD51-IN-1 DNA/RNA Synthesis
Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.
T2217 Cephalomannine Baccatin III Microtubule Associated
Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
T1478 Ondansetron hydrochloride dihydrate SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride 5-HT Receptor
Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, a...
T0132 Etoposide VP-16,VP-16-213 Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T2047 AG-1478 AG1478,NSC 693255,Tyrphostin AG-1478 EGFR , HCV Protease , Influenza Virus , HER , PDGFR
AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T16871 Semustine DNA Alkylator/Crosslinker
Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.
T6431 Levoleucovorin Calcium Calcium Levofolinate,CL307782 Others , Antifolate
Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
T28187 Nonabine
Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.
T1755 LY2090314 GSK-3
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a...
T6616 Ondansetron hydrochloride SN 307,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran 5-HT Receptor
Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
T1042 Granisetron hydrochloride BRL 43694A,Granisetron HCl 5-HT Receptor
Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
T21876 DC_AC50 Apoptosis , Others
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducin...
T24184 Itasetron DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL 5-HT Receptor
Itasetron (U 98079A) is a 5-hydroxytryptamine 3-receptor antagonist used to prevent age-related memory deficits in rats.Itasetron's antiemetic activity in animal models of cancer chemotherapy and radiation therapy may be...
T3924 Astragaloside II Astrasieversianin VIII TGF-beta/Smad
Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, ...
T28935 TDRL-551 Others
TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 µM) with potential anticancer activity.TDRL-551 inhibits RPA-DNA interaction and enhances the efficacy of platinum-based chemotherapy for lung...
T4451 Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium Apoptosis , Microtubule Associated
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
T6127 Rucaparib Phosphate AG-014699 phosphate,PF-01367338,AG-014699,PF-01367338 phosphate PARP
Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
T3716 Rolapitant SCH619734 Neurokinin receptor
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ...
T39024 PrNMI Cannabinoid Receptor
PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced pe...

Compounds

Endothall
T2747
Synonym:
Target: Others
RAD51-IN-1
T9271
Synonym:
Target: DNA/RNA Synthesis
Cephalomannine
T2217
Synonym: Baccatin III
Target: Microtubule Associated
Ondansetron hydrochloride dihydrate
T1478
Synonym: SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride
Target: 5-HT Receptor
Etoposide
T0132
Synonym: VP-16,VP-16-213
Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy
AG-1478
T2047
Synonym: AG1478,NSC 693255,Tyrphostin AG-1478
Target: EGFR, HCV Protease, Influenza Virus, HER, PDGFR
Semustine
T16871
Synonym:
Target: DNA Alkylator/Crosslinker
Levoleucovorin Calcium
T6431
Synonym: Calcium Levofolinate,CL307782
Target: Others, Antifolate
Nonabine
T28187
Synonym:
Target:
LY2090314
T1755
Synonym:
Target: GSK-3
Ondansetron hydrochloride
T6616
Synonym: SN 307,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran
Target: 5-HT Receptor
Granisetron hydrochloride
T1042
Synonym: BRL 43694A,Granisetron HCl
Target: 5-HT Receptor
DC_AC50
T21876
Synonym:
Target: Apoptosis, Others
Itasetron
T24184
Synonym: DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL
Target: 5-HT Receptor
Astragaloside II
T3924
Synonym: Astrasieversianin VIII
Target: TGF-beta/Smad
TDRL-551
T28935
Synonym:
Target: Others
Estramustine phosphate sodium
T4451
Synonym: Ro 21-8837/001,Estramustine phosphate disodium
Target: Apoptosis, Microtubule Associated
Rucaparib Phosphate
T6127
Synonym: AG-014699 phosphate,PF-01367338,AG-014699,PF-01367338 phosphate
Target: PARP
Rolapitant
T3716
Synonym: SCH619734
Target: Neurokinin receptor
PrNMI
T39024
Synonym:
Target: Cannabinoid Receptor
1 2 3
TargetMol